EVALUATION OF THREE MEDICINAL PLANTS OF BANGLADESHFOR THROMBOLYTIC POTENTIALS

Abstract

The crude methanol extracts of whole plant of Wedelia chinensis Osbeck. Merr., stem bark of
Mimosa diplotricha Sauvalle. and leaves of Bauhinia purpurea Roxb. as well as their hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screening
for thrombolytic activity. The extractives of W. chinensis demonstrated varying extent of clot
lysis activities within the range of 4.11 % to 44.24 %. The highest thrombolytic activity was
demonstrated by the carbon tetrachloride soluble fraction (44.24±0.48 %) when compared with
the standard thrombolytic drug streptokinase (66.77 %). Among the extractives of M.
diplotricha and B. malabarica the carbon tetrachloride soluble fraction (19.76±0.88 % clot
lysis) and the aqueous soluble fraction (25.83±0.88 %) revealed the highest thrombolytic
activities, respectively.