SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF COPPER (II) AND PALLADIUM (II) COMPLEXES OF 2- ((5-BROMOBENZO [D][1,3]-DIOXOL-4-YL) METHYLENE) HYDRAZINE1-CARBOTHIOAMIDE

Abstract

Equimolar amounts of 5-bromo-1,3-benzodioxole-4-carbaldehyde and thiosemicarbazide were
combined together and the 2-((5-bromobenzo[d][1,3]-dioxol-4-yl)methylene) hydrazine-1-
carbothioamide was prepared as a new bidentate complexing agent. The synthesized ligand
was reacted with Copper (II) and Palladium (II) ions yielding air stable complexes. For
quantification and characterization purposes; infrared spectra, electronic spectra, proton nuclear
magnetic resonance spectra and mass spectral studies were carried out on the obtained ligand
and it is metal complexes. Thermo gravimetric analysis and magnetic susceptibility
measurements were also used for characterization of metal complexes. The IR spectrum
showed that the ligand acts as a bidentate coordinates to the metal ions through the nitrogen and
Sulfur atoms. Measurements of magnetic susceptibility for Copper (II) and Palladium (II)
complexes were found to be 2.59 and 0.0 B.M respectively, suggested the octahedral and
square planar geometry respectively. The conductivity measurements revealed that the chelates
are non-electrolytes and electrolytes respectively. An in vitro antimicrobial investigation was
also carried out for the free ligand and its metal complexes against bacterial and fungal strains,
to assess their antimicrobial properties by disc diffusion method. Antimicrobial activity of the
prepared complexes showed higher activity than the free ligand.