FORMULATION AND EVALUATION OF FLURBIPROFEN TABLET BY NOVEL HOLE TECHNOLOGY

Abstract

The objective of the present study was to develop flurbiprofen quick dissolving tablets by Hole technology. Once these Fast dissolving tablets contact with gastric fluids, the fluid enters the hole formed within the tablet and result in immediate breaking of the Tablet. This quick disintegration of tablets is additionally influenced by the formation of latest absolute space. The ready FDTs was subjected to numerous pre and post formulation studies. Its dissolution and disintegration rate was compared with the formulation (without hole). In-vitro drug release of FDTs F5 showed virtually 98.92% of the drug was in fourteen minute, whereas the formulation F1 showed the 97.07% drug release in seventeen minute. Overall, this method is novel and most helpful for formulation into quick dissolving tablet.