PALLADIUM (II) AND PLATINUM (II) COMPLEXES OF 1-METHYL-2- IMIDAZOLECARBOXALDEHYDE THIOSEMICARBAZONE, SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
Keywords:
Thiosemicarbazone,, Synthesis, X-ray crystal structure, IR, UV-Vis, NMR and antimicrobial activityAbstract
Schiff bases are the most widely used organic compounds. They have been shown to exhibit a
broad range of biological activities, including antifungal, antibacterial, antimalarial,
antiproliferative, anti-inflammatory, antiviral and antipyretic properties. These compounds are
very important in medicinal and pharmaceutical fields because of their wide spectrum of
biological activities. Such an attempt made here to synthesis; 1-methyl-2-
imidazolecarboxaldehyde thiosemicarbazone by reacting equimolar amounts of
thiosemicarbazide and the corresponding imidazolecarbaldehyde. The resulting ligand and its
transition metal complexes with Platinum(II) and Palladium(II) were characterized by different
spectroscopic techniques (IR, UV-Vis, Ms, NMR and X-ray). The ligand and its metals
complexes were exhibit a moderate antimicrobial activity against four bacteria; Bacillus cereus,
Staphylococcus aureus (Gram-positive). Escherichia coli and Salmonella typhimurium (Gramnegative) and one Fungi; Candida albicans.
