ATYPICAL CHRONIC MYELOID LEUKEMIA BCR-ABL 1 NEGATIVE: A CASE REPORT AND LITERATURE REVIEW

Abstract

Atypical chronic myeloid leukemia BCR-ABL negative is rare myelodysplastic
syndrome/myeloproliferative neoplasm for which there is no current standard of therapy.
Patients with aCML had pronounced immature granulocytosis and granulocytotic dysplasia in
their blood smears. We admitted a 60-year-old man with splenomegaly, hyperleukocytosis,
anemia, and thrombocytopenia; after cytology, cytogenetic, and molecular biology analyses of
bone marrow, we diagnosed aCML using 2016 World Health Organization classification.
Chemotherapy was used to treat the patient at first, but the patient’s anemia worsened. This
prompted a modification in treatment.