A NOVEL APPROACH TO DELIVER THERAPEUTIC AGENTS USINGIN SITU FORMING IMPLANT BASED ON SOLVENT INDUCED PHASE SEPARATION TECHNIQUE FOR LONG TERM CONTROLLEDRELEASE

Abstract

Biodegradable injectable in situ forming drug delivery systems represent an attractive alternative
to microspheres and conventional implants as parenteral depot systems. In situ forming Implant
concept includes biodegradable polymers dissolved in or diluted with water miscible,
physiological compatible organic Solvents. Upon injection through i.m. or S.c. solvent dissipates
into the physiological space & due to insolubility of polymer in physiological fluid it gets
precipitated out & forms adepot with entrapped drug inside it. Drug is released from these depots
either by diffusion or erosion of it. ISFI are capable to deliver them for few weeks to several
months. The desired drug release profile can be obtained by modifying polymer concentration,
combination of hydrophilic & hydrophobic biocompatible solvents & by using additives. Various
therapeutic agents which include synthetic drugs, hormones & other protein drugs are
successfully formulated& patented with this technology. Here in this review article these topics
are discussed briefly.