EFFECT OF INTRAVENOUS ZOLENDRONIC ACID ON BONE MINERAL DENSITY IN POST MENOPAUSAL WOMEN WITH LOWBONE MINERAL DENSITY OF NORTH WEST PART OF RAJASTHAN

Abstract

Background : Menopause is the period during which systemic oestrogen level is reduced.
During postmenopausal period, bone remodelling cycle is distorted and is occasionally
associated with low bone mass which is the major determinant of bone strength. Zoledronic
acid, a third generation bisphosphonates available as an alternative formulation approved for
the treatment of postmenopausal women.
Aim : To study the efficacy of zolendronic acid in the post menopausal women with low
BMD through change in BMD and to assess the adverse effects, compliance and adherence
of the of zoledronic acid in the post menopausal women with low BMD.
Results : Mean BMD on day 1 was 0.4380.039 while on 1 year it was 0.4800.037 and the
difference was found highly significant. Mean T-score on day 1 was -2.2800.677 and on 1
year follow up it was -1.6420.644 and the difference was found statistically highly
significant (p<0.001). We divided T-Score into two groups i.e. >-2.50 and -1 to -2.5. Out of
total 100 patients, on day 1 total 37 patients were found in T-Score group >-2.5 group and
out of them 5, 25 and 7 belonged to <60, 61-70 and >70 years of age group and total 63
patients were found in T-Score group -1to-2.5group and out of them 20, 37 and 6 belonged
to <60, 61-70 and >70 years of age group.
Conclusion : In conclusion zoledronic acid was effective drug for the treatment of the
postmenopausal women with the low bone mineral density with a once yearly administration
with only significant infusion related reaction, which can be managed conservatively.
Zoledronic acid is also safe without effect on renal and hepatic function, and without any
adverse serious reaction, though a large study and long follow up required to reach some
definite conclusion.