FORMULATION AND EVALUATION OF TOPICAL EMULGEL OF ANTIACNE AGENT

Abstract

The aim of present work was to develop a topical emulgel of antiacne agent, which would effectively deliver the drug without pain or irritation. The major objectives behind the formulation is enhancing the topical delivery of hydrophobic drug (Adapalene), and increases the Absorption of adapalene through human skin by formulating Adapalene Emulgel using Carbopol 934, Hydroxypropyl methylcellulose (HPMCK100M), and combination of both polymers. Isopropyl myristate (IPM) is used as permeation enhancer. The prepared emulgel were evaluated for their physical appearance, pH determination, viscosity, spreadability, extrudability, in vitro drug release, skin irritation test, and stability. All the prepared Emulgel formulation showed acceptable pH, Drug contents, Spreadability, Extrudability, Viscosity. Formulation with combination of both polymers 0.5 % (Carbopol 934 + HPMC K100M) and high amount of emulsifiers (4%) was found to give higher release profile 83.73 %. In-vitro diffusion profile of Adapalene emulgel (optimized batch F10) indicate that 83.73% drug release within 24 hrs, while 77.56% of marketed formulation. Accelerated stability studies were conducted as per ICH guidelines at 40°C± 2°C temperature and 75%RH± 5%RH for 1 Month and indicated that optimized formulation F10 were stable. Skin irritation studies of optimized formulation F10 was performed using rabbit as an animal model for 24 hrs and no erythema and edema were recorded after 24 hrs. The result obtained shows that Topical Emulgel of Adapalene can be used as effective topical system for treatment of Acne.